• Neuronal cells have highly developed

  2020-02-10

  

  Neuronal px12 have highly developed ER, which makes them susceptible to loss of ER function following exposure to various agents, which leads to apoptosis (Lindholm et al., 2006, Katayama et al., 2004). Multiple pathways may be involved in ER stress-initiated apoptosis. Among them, the PKR-like end

• br The ubiquitin proteasome system The ubiquitin proteasome

  2020-02-10

  

  The ubiquitin proteasome system The ubiquitin proteasome system (UPS) plays a significant role in the regulation of cell growth and survival, in addition to maintaining cellular homeostasis. By means of the UPS, WS 3 can precisely and temporally degrade approximately 80% of the entire proteome.

• In attempts to further purify

  2020-02-10

  

  In attempts to further purify [His]6-Artemis, numerous matrices were assessed including anion and cation exchange, and 2272 interaction chromatography. The results from these matrices were universally poor (data not shown). Fractionation via adsorption chromatography on a hydroxyapatite (HAP) matri

• Primases are classified into two major groups first the DnaG

  2020-02-10

  

  Primases are classified into two major groups: first, the DnaG primases, found in bacteria and bacteriophages, and second, the archaeoeukaryotic primases. Remarkably, bacterial and archaeoeukaryotic primases have no structural similarity and, presumably, evolved independently (Leipe et al., 1999). T

• Various domains of the HSA molecule have

  2020-02-08

  

  Various domains of the HSA molecule have also been used to make bioconjugates with increased stability, better targeting properties, and/or extended half-lives in blood. For example, domain I of HSA has been used in the preparation of antibody conjugates. This was achieved through the use of a cyclo

• There are two general approaches to building Bayesian networ

  2020-02-08

  

  There are two general approaches to building Bayesian networks for the purpose of risk assessment. Researchers can implement static models that predict risk or survival at a snap-shot of time. For example, Loghmanpour et al. [10] created Bayesian network-based risk assessment models for patient data

• br Outcome of COX overexpression Although a causal role for

  2020-02-08

  

  Outcome of COX-2 overexpression Although a causal role for COX-2 has been proposed, mechanisms by which COX-2 function contributes to the pathogenesis of hyperplastic disease are not well defined. To examine if there is any correlation between COX-2 and p53 protein levels, Kumagai et al. [15] rec

• GDC-0199 In conclusion the data suggest that doses of COX in

  2020-02-08

  

  In conclusion, the data suggest that doses of COX-2 inhibitors and EP1 receptor antagonists which have previously been reported to exert disease modulating or antiepileptic drug potentiating effects do not negatively affect seizure control in temporal lobe epilepsy. The contrasting impact of the EP1

• MTX and MTXPGs block the activity of the

  2020-02-07

  

  MTX and MTXPGs block the activity of the key enzyme DHFR (Fig. 1), which converts folates to their active forms – dihydrofolate (DHF) and tetrahydrofolate (THF). MTXPGs also potently inhibit thymidylate synthase (TS). Furthermore, during dTMP synthesis, TS utilizes the cofactor 5,10-methylene THF, w

• In contrast to PEGylated proteins which tend to have reduced

  2020-02-07

  

  In contrast to PEGylated proteins which tend to have reduced Paclitaxel in the body relative to their native counterparts, proteins conjugated to albumin tend to accumulate in certain locales in vivo. This means that albumin-based drug carrier systems have particular applications in the field of ch

• Many authors have described the existence of correlation bet

  2020-02-07

  

  Many authors have described the existence of correlation between viability and moisture content and therefore, water availability. Sabuquillo et al. (2010) demonstrated that only Penicillium oxalicum conidial formulations whose initial moisture contents ranged between 5 and 14% retained their viabil

• Co operation or synergy between PKA and

  2020-02-07

  

  Co-operation or synergy between PKA and Epac has been recently reported in PCCL3 thyroid cell line in which cAMP is pro-mitogenic, in Neratinib sale to VSMC [19]. Our study demonstrates for the first time that PKA and Epac also synergise to inhibit cell proliferation in a cell type where cAMP in an

• Colony stimulating factor receptor CSF R or cFMS is

  2020-02-06

  

  Colony stimulating factor-1 receptor (CSF-1R or cFMS) is a type III receptor tyrosine kinase. It is activated by binding with CSF-1 and IL-34, which stimulates differentiation, proliferation, survival and migration of monocyte-macrophage lineage cells., , , Also, macrophages produce inflammatory me

• This pathway appears to have

  2020-02-05

  

  This pathway appears to have importance in epilepsy. DGKε(−/−) mice had significantly fewer motor seizure and epileptic events compared with DGKε(+/+) mice [18]. This could be explained by the fact that in the knockout mice a greater fraction of the SAG would be converted to 2-AG. 2-AG itself is kno

• Two key enzymes play important roles in the bioconversion

  2020-02-05

  

  Two key enzymes play important roles in the bioconversion of xylitol from d-arabitol, namely d-arabitol dehydrogenase (ArDH) and NADH-dependent xylitol dehydrogenase (XDH), respectively (Qi et al., 2014). In an earlier study, we developed a high xylitol yield strain by expressing xdh in E. coli BL21

15676 records 885/1046 page Previous Next First page 上5页 881882883884885 下5页 Last page