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Irinotecan (CPT-11): Applied Workflows for Colorectal Can...
2025-09-30
Irinotecan, a leading topoisomerase I inhibitor, is revolutionizing colorectal cancer research through its integration into advanced assembloid and tumor microenvironment models. This guide delivers practical protocols, troubleshooting insights, and experimental strategies to maximize the impact of Irinotecan across preclinical studies, from DNA damage assessment to personalized therapeutic screening.
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Amorolfine Hydrochloride in Mechanistic Fungal Cell Physi...
2025-09-29
Explore how Amorolfine Hydrochloride, a potent antifungal reagent, enables advanced research into fungal cell membrane integrity and ploidy stress. This article uniquely integrates recent genetic findings with antifungal drug mechanisms, offering new insights for fungal infection and resistance studies.
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Capecitabine: Mechanisms and Innovations in Tumor-Targete...
2025-09-28
Explore the unique tumor-selective mechanisms of Capecitabine, a leading fluoropyrimidine prodrug, and its advanced applications in preclinical oncology research. This article offers a deep dive into apoptosis induction, drug delivery, and emerging translational models, distinguishing it from standard protocols.
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Amorolfine Hydrochloride: Unlocking Fungal Cell Integrity...
2025-09-27
Discover how Amorolfine Hydrochloride empowers advanced fungal infection research by unraveling membrane integrity under high-ploidy conditions. This article uniquely explores the intersection of antifungal mechanism, cell surface stress, and genome doubling, providing fresh insights for antifungal resistance studies.
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Amorolfine Hydrochloride: Molecular Insights and New Hori...
2025-09-26
Explore advanced scientific insights into Amorolfine Hydrochloride, a leading antifungal reagent, and its unique role in dissecting fungal cell membrane integrity and ploidy stress. This article provides a molecular-level analysis of antifungal drug mechanisms and highlights novel research applications.
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Cyclopamine in Translational Oncology: From Mechanism to ...
2025-09-25
Explore Cyclopamine, a potent Hedgehog signaling inhibitor, as a translational bridge between developmental biology and advanced cancer research. This article uniquely synthesizes molecular mechanisms, teratogenicity, and model-driven innovations, setting it apart from prevailing reviews.
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Nitrocefin in β-Lactamase Evolution: Profiling Resistance...
2025-09-24
Explore how Nitrocefin, a premier chromogenic cephalosporin substrate, enables advanced β-lactamase detection and reveals the dynamics of antibiotic resistance evolution, including horizontal gene transfer. Discover novel applications in multidrug-resistant pathogen research and resistance profiling.
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DMXAA (Vadimezan): Emerging Mechanistic Insights for Tumo...
2025-09-23
Explore the multifaceted role of DMXAA (Vadimezan, AS-1404), a potent vascular disrupting agent for cancer research, focusing on its mechanisms as a DT-diaphorase inhibitor and apoptosis inducer in tumor endothelial cells. This article provides novel perspectives on DMXAA’s integration with endothelial signaling pathways and tumor microenvironment modulation.
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In glaucoma the primary retinal defect appears in the
2025-03-03
In glaucoma, the primary retinal defect appears in the GCL, whereas the other retinal layers appear normal (Kendell et al., 1995). In the current work, chronic elevation of IOP induced RGC apoptosis, especially in the GCL, and α2 adrenergic treatment reduced RGC apoptosis. Various studies have repor
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Whether similar mechanisms play a role
2025-03-03
Whether similar mechanisms play a role in adiponectin signal transduction and whether additional proteins are recruited to adiponectin receptors via APPL1 has not been analysed so far. Although it has been clearly established that APPL1 is a downstream adaptor protein in adiponectin signal transduct
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The disease stimulatory effects of hyperadiponectinemia in
2025-03-03
The disease-stimulatory effects of hyperadiponectinemia in patients contradict a previous view based on studies of preclinical models showing that APN might be beneficial for AD [8]. Indeed, despite the action of APN as a risk factor in patients with AD, APN is protective against oxidative stress-in
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br Experimental procedure br Introduction Migraine is
2025-03-03
Experimental procedure Introduction Migraine is a debilitating neurovascular disorder characterized by recurring unilateral pulsating headaches of moderate to severe intensity, associated with nausea, photophobia and/or phonophobia, lasting from 4 to 72 h (Headache Classification Committee of
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br Conflict of interest br Acknowledgement
2025-03-03
Conflict of interest Acknowledgement This study was supported by a grant from University Grants Commission - Basic Scientific Research (UGC-BSR), New Delhi, India (UGC-BSR No:F-7-115/2007). Introduction The G protein-coupled receptors activated by extracellular adenosine (Ado), called Aden
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br Methods br Results br
2025-03-03
Methods Results Discussion First, the calcitonin receptor isolated from non-PD TA tissue and PD plaque tissue were characterized. The results showed that both cell groups were positive for vimentin and negative for desmin suggesting that these cells were fibroblasts. It was also observed t
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PC is considered as a cancer of the epigenome Grasso
2025-03-03
PC is considered as a cancer of the epigenome (Grasso et al., 2012, Robinson et al., 2015). Our results demonstrate that the interaction of AR with ACK1 drives the positive feedback epigenetic circuitry that is ultimately conducive to promote AR transcription. Further, this circuitry subjugates AR t