• Cyclopamine in Translational Oncology: From Mechanism to ...

  2025-09-25

  Explore Cyclopamine, a potent Hedgehog signaling inhibitor, as a translational bridge between developmental biology and advanced cancer research. This article uniquely synthesizes molecular mechanisms, teratogenicity, and model-driven innovations, setting it apart from prevailing reviews.

• Nitrocefin in β-Lactamase Evolution: Profiling Resistance...

  2025-09-24

  Explore how Nitrocefin, a premier chromogenic cephalosporin substrate, enables advanced β-lactamase detection and reveals the dynamics of antibiotic resistance evolution, including horizontal gene transfer. Discover novel applications in multidrug-resistant pathogen research and resistance profiling.

• DMXAA (Vadimezan): Emerging Mechanistic Insights for Tumo...

  2025-09-23

  Explore the multifaceted role of DMXAA (Vadimezan, AS-1404), a potent vascular disrupting agent for cancer research, focusing on its mechanisms as a DT-diaphorase inhibitor and apoptosis inducer in tumor endothelial cells. This article provides novel perspectives on DMXAA’s integration with endothelial signaling pathways and tumor microenvironment modulation.

• In glaucoma the primary retinal defect appears in the

  2025-03-03

  

  In glaucoma, the primary retinal defect appears in the GCL, whereas the other retinal layers appear normal (Kendell et al., 1995). In the current work, chronic elevation of IOP induced RGC apoptosis, especially in the GCL, and α2 adrenergic treatment reduced RGC apoptosis. Various studies have repor

• Whether similar mechanisms play a role

  2025-03-03

  

  Whether similar mechanisms play a role in adiponectin signal transduction and whether additional proteins are recruited to adiponectin receptors via APPL1 has not been analysed so far. Although it has been clearly established that APPL1 is a downstream adaptor protein in adiponectin signal transduct

• The disease stimulatory effects of hyperadiponectinemia in

  2025-03-03

  

  The disease-stimulatory effects of hyperadiponectinemia in patients contradict a previous view based on studies of preclinical models showing that APN might be beneficial for AD [8]. Indeed, despite the action of APN as a risk factor in patients with AD, APN is protective against oxidative stress-in

• br Experimental procedure br Introduction Migraine is

  2025-03-03

  

  Experimental procedure Introduction Migraine is a debilitating neurovascular disorder characterized by recurring unilateral pulsating headaches of moderate to severe intensity, associated with nausea, photophobia and/or phonophobia, lasting from 4 to 72 h (Headache Classification Committee of

• br Conflict of interest br Acknowledgement

  2025-03-03

  

  Conflict of interest Acknowledgement This study was supported by a grant from University Grants Commission - Basic Scientific Research (UGC-BSR), New Delhi, India (UGC-BSR No:F-7-115/2007). Introduction The G protein-coupled receptors activated by extracellular adenosine (Ado), called Aden

• br Methods br Results br

  2025-03-03

  

  Methods Results Discussion First, the calcitonin receptor isolated from non-PD TA tissue and PD plaque tissue were characterized. The results showed that both cell groups were positive for vimentin and negative for desmin suggesting that these cells were fibroblasts. It was also observed t

• PC is considered as a cancer of the epigenome Grasso

  2025-03-03

  

  PC is considered as a cancer of the epigenome (Grasso et al., 2012, Robinson et al., 2015). Our results demonstrate that the interaction of AR with ACK1 drives the positive feedback epigenetic circuitry that is ultimately conducive to promote AR transcription. Further, this circuitry subjugates AR t

• 78 4 br LOX in pancreatic cancer LOX is a

  2025-03-03

  

  5-LOX in pancreatic cancer 5-LOX is a key player in pancreatic cancer (PC) progression. The upregulation of 5-LOX mRNA has been observed in pancreatic adenocarcinoma (PDAC) and also in neoplastic pancreatic tissues (Kennedy et al., 2003). Higher levels of 5-LOX transcripts (messengers) are presen

• br ATX LPA pathway in animal models of

  2025-03-03

  

  ATX–LPA pathway in animal models of rheumatoid arthritis Several animal models have been used to characterize the mechanisms involved in the pathogenesis of arthritis and to test new therapeutic strategies. The collagen-induced arthritis (CIA) model (Courtenay et al., 1980, Luross and Williams, 2

• br Disclosure statement br Acknowledgements The work was sup

  2025-03-03

  

  Disclosure statement Acknowledgements The work was supported by the National Science Foundation of China (Nos. 81273526, 81473268) and Natural Science Foundation of Colleges and Universities (Nos. KJ2017A197). What is already known What this article adds Introduction Sevoflurane is o

• Several alterations have been or can be associated

  2025-03-01

  

  Several alterations have been or can be associated to the decreased tolerance of steatotic liver to I/R injury. Previous studies demonstrated that upregulation of the mitochondrial uncoupling protein-2 (UP2) is strictly related to the increase of I/R injury in steatotic liver [4]. UPR induction is c

• br Acknowledgment Supported in part by NIH R EB

  2025-03-01

  

  Acknowledgment Supported in part by NIH1R21EB012707 (Biegon, Anat PI). Introduction Estrogens exert pleiotropic effects on a variety of morphological, physiological and behavioral responses in all vertebrate classes ranging from fishes to mammals. Effects of estrogens in the hif pathway conc

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